I couldn't use either Actifolate or Symphora so I went with FolaPro L-5-MethylTetrahydrofolate from Metagenics together with methylcobalamin. It's helped a lot with the double MTHFR mutation that I have. The other ones that I tried didn't make me feel good. Symphora contained a lot more DHEA than what my blood could handle. FolaPro, on the other hand, hasn't given me any side effects. Currently, I take 4000 mg per day.